The FRAT™ (Folate Receptor Antibody Test) is a patented diagnostic blood test that screens for autoantibodies that bind to the folate receptor alpha (FRα), a protein responsible for transporting folate (vitamin B9) across cell membranes. Folate is vital for healthy cell growth and function, supporting the development and maintenance of tissues and organs.
These autoantibodies can block and interfere with the proper absorption of folate into critical tissues such as in the brain potentially leading to neurological issues and developmental delays, and have been linked to conditions such as Autism Spectrum Disorders and Cerebral Folate Deficiency Syndrome.
The FRAT test is a simple test where a blood sample (typically 2 to 4 ml of blood) is collected and sent for analysis. The test uses an immunoassay technique (like ELISA or RIA) to detect and measure the concentration of these autoantibodies and can help to provide comprehensive results for assessing a child’s neurological condition.
If the FRAT test detects autoantibodies, a healthcare professional can discuss treatment options, which may involve using alternative folate forms that bypass the blocked transport system or making dietary adjustments.